Osthole: A Promising Lead Compound for Drug Discovery from a Traditional Chinese Medicine (TCM)

Natural products have always been important resources either as therapeutic agents or as lead compounds for the production of pharmaceutical compounds. Osthole, 7-methoxy-8-(3-methyl-2-butenyl) coumarin, an ingredient of a Traditional Chinese Medicine(TCM), has received considerable attention recent...

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Bibliographic Details
Published inNatural product communications Vol. 4; no. 2; pp. 297 - 302
Main Authors You, Lisha, Feng, Song, An, Rui, Wang, Xinhong
Format Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.02.2009
Subjects
Coumarins - chemistry
Coumarins - pharmacology
Drug Discovery
Drugs, Chinese Herbal - chemistry
HeLa Cells
Humans
Medicine, Chinese Traditional
Molecular Biology
biological activity
drug discovery
Osthole
natural product
lead compound
TCM
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Summary:Natural products have always been important resources either as therapeutic agents or as lead compounds for the production of pharmaceutical compounds. Osthole, 7-methoxy-8-(3-methyl-2-butenyl) coumarin, an ingredient of a Traditional Chinese Medicine(TCM), has received considerable attention recently because of its significant and diverse pharmacological activities, including anticancer, antisteoporotic, and antiproliferative, which make it a very promising natural lead compound for new drug discovery. The present work summarizes the related biological information on osthole and its analogues and proposes the possibility of its development as a promising lead compound for drug discovery.
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ISSN:1934-578X
1555-9475
DOI:10.1177/1934578X0900400227