The Role of Heparan Sulfate in Inflammation, and the Development of Biomimetics as Anti-Inflammatory Strategies

Key events that occur during inflammation include the recruitment, adhesion, and transmigration of leukocytes from the circulation to the site of inflammation. These events are modulated by chemokines, integrins, and selectins and the interaction of these molecules with glycosaminoglycans, predomina...

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Bibliographic Details
Published inJournal of Histochemistry & Cytochemistry Vol. 66; no. 4; pp. 321 - 336
Main Authors Farrugia, Brooke L., Lord, Megan S., Melrose, James, Whitelock, John M.
Format Book Review Journal Article
LanguageEnglish
Published Los Angeles, CA SAGE Publications 01.04.2018
Subjects
Reviews
glycosaminoglycans
heparin
heparan sulfate
innate immunity
inflammation
extracellular matrix
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Summary:Key events that occur during inflammation include the recruitment, adhesion, and transmigration of leukocytes from the circulation to the site of inflammation. These events are modulated by chemokines, integrins, and selectins and the interaction of these molecules with glycosaminoglycans, predominantly heparan sulfate (HS). The development of HS/heparin mimetics that interfere or inhibit the interactions that occur between glycosaminoglycans and modulators of inflammation holds great potential for use as anti-inflammatory therapeutics. This review will detail the role of HS in the events that occur during inflammation, their interaction and modulation of inflammatory mediators, and the current advances in the development of HS/heparin mimetics as anti-inflammatory biotherapeutics.
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ISSN:0022-1554
1551-5044
DOI:10.1369/0022155417740881