Marburg Hemorrhagic Fever Associated with Multiple Genetic Lineages of Virus

• Published in: The New England journal of medicine Vol. 355; no. 9; pp. 909 - 919
• Main Authors: Bausch, Daniel G, Nichol, Stuart T, Muyembe-Tamfum, Jean Jacques, Borchert, Matthias, Rollin, Pierre E, Sleurs, Hilde, Campbell, Patricia, Tshioko, Florimund K, Roth, Catherine, Colebunders, Robert, Pirard, Patricia, Mardel, Simon, Olinda, Loku A, Zeller, Hervé, Tshomba, Antoine, Kulidri, Amayo, Libande, Modeste L, Mulangu, Sabue, Formenty, Pierre, Grein, Thomas, Leirs, Herwig, Braack, Leo, Ksiazek, Tom, Zaki, Sherif, Bowen, Michael D, Smit, Sheilagh B, Leman, Patricia A, Burt, Felicity J, Kemp, Alan, Swanepoel, Robert
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 31.08.2006
• Subjects: Adolescent; Adult; Aged; Animals; Biological and medical sciences; Child; Child, Preschool; Democratic Republic of the Congo - epidemiology; Disease Outbreaks; Disease Reservoirs; Ebola virus; Epidemics; Fatalities; Female; Fever; General aspects; Genetics; Gold; Hemorrhage; Hospitals; Human viral diseases; Humans; Infant; Infant, Newborn; Infectious diseases; Male; Marburg disease, ebola disease; Marburg Virus Disease - epidemiology; Marburg Virus Disease - mortality; Marburg Virus Disease - transmission; Marburg Virus Disease - virology; Marburgvirus - genetics; Marburgvirus - isolation & purification; Medical sciences; Middle Aged; Mining; Seasons; Sequence Analysis, DNA; Tropical viral diseases; Viral diseases; Democratic Republic of the Congo; Infection; Medicine; Virus; Hemorrhagic fever; Association; Multiple; Viral disease; Arbovirus disease; Marburg disease; Genetics
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa051465

An outbreak of 154 cases of Marburg hemorrhagic fever in the Democratic Republic of the Congo between 1998 and 2000 had a case fatality rate of 83 percent. Multiple insertions of the virus into the population were identified and were associated with independent chains of human transmission. An outbreak of Marburg hemorrhagic fever in the Democratic Republic of the Congo between 1998 and 2000 had a case fatality rate of 83 percent. Multiple insertions of the virus into the population were identified and were associated with independent chains of human transmission. The filoviruses Marburg and Ebola cause severe hemorrhagic fevers with high case fatality rates. Marburg virus (Lake Victoria subtype) of the family Filoviridae was first isolated and Marburg hemorrhagic fever first described in 1967 during outbreaks in Germany and Yugoslavia. These outbreaks were linked to infected monkeys imported from Uganda. 1 – 4 Three minor outbreaks involving one to three cases were subsequently reported in Africa between 1975 and 1987. 5 – 9 Transmission of the virus between humans is poorly understood, and the natural reservoir remains unknown. In October 1998, the chief medical officer for Watsa Zone in northeastern Democratic Republic of the . . .