Neural correlates of syntactic processing in the nonfluent variant of primary progressive aphasia

• Published in: The Journal of neuroscience Vol. 30; no. 50; pp. 16845 - 16854
• Main Authors: Wilson, Stephen M, Dronkers, Nina F, Ogar, Jennifer M, Jang, Jung, Growdon, Matthew E, Agosta, Federica, Henry, Maya L, Miller, Bruce L, Gorno-Tempini, Maria Luisa
• Format: Journal Article
• Language: English
• Published: United States Society for Neuroscience 15.12.2010
• Subjects: Aged; Atrophy - pathology; Brain Mapping - methods; Comprehension - physiology; Female; Frontal Lobe - pathology; Frontal Lobe - physiopathology; Humans; Language; Magnetic Resonance Imaging - methods; Male; Primary Progressive Nonfluent Aphasia - physiopathology; Speech Perception; Temporal Lobe - physiology
• ISSN: 0270-6474; 1529-2401
• DOI: 10.1523/jneurosci.2547-10.2010

The left posterior inferior frontal cortex (IFC) is important for syntactic processing, and has been shown in many functional imaging studies to be differentially recruited for the processing of syntactically complex sentences relative to simpler ones. In the nonfluent variant of primary progressive aphasia (PPA), degeneration of the posterior IFC is associated with expressive and receptive agrammatism; however, the functional status of this region in nonfluent PPA is not well understood. Our objective was to determine whether the atrophic posterior IFC is differentially recruited for the processing of syntactically complex sentences in nonfluent PPA. Using structural and functional magnetic resonance imaging, we quantified tissue volumes and functional responses to a syntactic comprehension task in eight patients with nonfluent PPA, compared to healthy age-matched controls. In controls, the posterior IFC showed more activity for syntactically complex sentences than simpler ones, as expected. In nonfluent PPA patients, the posterior IFC was atrophic and, unlike controls, showed an equivalent level of functional activity for syntactically complex and simpler sentences. This abnormal pattern of functional activity was specific to the posterior IFC: the mid-superior temporal sulcus, another region modulated by syntactic complexity in controls, showed normal modulation by complexity in patients. A more anterior inferior frontal region was recruited by patients, but did not support successful syntactic processing. We conclude that in nonfluent PPA, the posterior IFC is not only structurally damaged, but also functionally abnormal, suggesting a critical role for this region in the breakdown of syntactic processing in this syndrome.