Clinical Utility of Flow Cytometry for Detection of Anti-Jkb IgM in Acute Haemolytic Transfusion Reaction

Acute hemolytic transfusion reaction (AHTR) is a rare but life-threatening complication of transfusion. We herein report a case of anti-Jkb IgM-related AHTR. Two hours after an 80-year-old man with myelodysplastic syndrome received a packed red blood cell (RBC) A+/Rh-/Jkb+/c- transfusion, he develop...

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Published inInternal Medicine Vol. 63; no. 9; pp. 1273 - 1275
Main Authors Nagaharu, Keiki, Izumi, Takuya, Maruyama, Mitsuko, Sugimoto, Yuka, Ohishi, Kohshi, Tawara, Isao, Usui, Eiji, Tamaki, Shigehisa
Format Journal Article
LanguageEnglish
Published Tokyo The Japanese Society of Internal Medicine 01.05.2024
Japan Science and Technology Agency
Subjects
AHTR
Case Report
Case reports
Erythrocytes
Flow cytometry
IgM
Immunoglobulin M
Jkb antigen
Myelodysplastic syndrome
transfusion
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Summary:Acute hemolytic transfusion reaction (AHTR) is a rare but life-threatening complication of transfusion. We herein report a case of anti-Jkb IgM-related AHTR. Two hours after an 80-year-old man with myelodysplastic syndrome received a packed red blood cell (RBC) A+/Rh-/Jkb+/c- transfusion, he developed acute respiratory failure and a fever. Although he had tested negative in routine screening tests, the 37°C normal saline test was weakly positive for Jkb. We confirmed the presence of anti-Jkb IgM in the patient's serum by flow cytometry. This case demonstrates the potential utility of flow cytometry for IgM detection.
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Correspondence to Keiki Nagaharu, keiki-nagaharu@med.mie-u.ac.jp
ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.2639-23