Thyroid Papillary Adenocarcinoma in a Woman with Peutz-Jeghers Syndrome

We present a rare case of Peutz-Jeghers (P-J) syndrome in a 29-year-old woman who developed adenocarcinoma of the thyroid and polyps in the gastrointestinal tract. Polyps removed from the stomach, colon and ileum showed features typical of hamartomas. Histological examination indicated that the tumo...

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Published inInternal Medicine Vol. 31; no. 9; pp. 1117 - 1119
Main Authors YAMAMOTO, Masahiro, HOSHINO, Hiroshi, ONIZUKA, Toshio, ICHIKAWA, Masafumi, KAWAKUBO, Akitoshi, HAYAKAWA, Seijun
Format Journal Article
LanguageEnglish
Published Japan The Japanese Society of Internal Medicine 1992
Subjects
Adenocarcinoma, Papillary
Adult
autosomal dominant inheritance
extraintestinal malignancy
Female
gastrointestinal polyps
Hamartoma
Humans
Neoplasms, Multiple Primary
Peutz-Jeghers Syndrome
Thyroid Neoplasms
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Summary:We present a rare case of Peutz-Jeghers (P-J) syndrome in a 29-year-old woman who developed adenocarcinoma of the thyroid and polyps in the gastrointestinal tract. Polyps removed from the stomach, colon and ileum showed features typical of hamartomas. Histological examination indicated that the tumor resected from the right lobe of the thyroid was a papillary adenocarcinoma. This appears to be the first precise report of a P-J syndrome associated with thyroid carcinoma. This case adds an example of predisposition of P-J syndrome to extraintestinal malignancy and indicates the importance of long-term observation of malignancy. (Internal Medicine 31 : 1117-1119, 1992)
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ISSN:0918-2918
1349-7235
DOI:10.2169/internalmedicine.31.1117