Reactivation of Hepatitis B With Reappearance of Hepatitis B Surface Antigen After Chemotherapy and Immunosuppression

• Published in: Clinical gastroenterology and hepatology Vol. 7; no. 10; pp. 1130 - 1137
• Main Authors: Palmore, Tara N., Shah, Neeral L., Loomba, Rohit, Borg, Brian B., Lopatin, Uri, Feld, Jordan J., Khokhar, Farooq, Lutchman, Glen, Kleiner, David E., Young, Neal S., Childs, Richard, Barrett, A. John, Liang, T. Jake, Hoofnagle, Jay H., Heller, Theo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2009
• Subjects: Adult; Anti-HIV Agents - adverse effects; Anti-HIV Agents - therapeutic use; Female; Gastroenterology and Hepatology; Hepatitis B - chemically induced; Hepatitis B Antibodies - blood; Hepatitis B Surface Antigens - blood; HIV Infections - complications; Humans; Immunosuppressive Agents - adverse effects; Immunosuppressive Agents - therapeutic use; Male; Middle Aged; Stem Cell Transplantation - adverse effects; Virus Activation - drug effects; anti-HBc; anti-HBs; GVHD; CML; HIV; ALP; antibody to hepatitis B core antigen; human immunodeficiency virus; chronic myelogenous leukemia; alkaline phosphatase; antibody to hepatitis B surface antigen; graft-versus-host disease
• ISSN: 1542-3565; 1542-7714; 1542-7714
• DOI: 10.1016/j.cgh.2009.06.027

HBV infection may reactivate in the setting of immunosuppression, although the frequency and consequences of HBV reactivation are not well known. We report 6 patients who experienced loss of serologic markers of hepatitis B immunity and reappearance of HBsAg in the serum as a result of a variety of...