The Effectiveness and Practicality of a Novel Barrier Membrane for the Open Window in Maxillary Sinus Augmentation with a Lateral Approach, with Risk Indicators for Bone Graft Displacement and Bone Height Decrease: A Prospective Study in Humans

• Published in: Bioengineering (Basel) Vol. 10; no. 10; p. 1110
• Main Authors: Yamaguchi, Kikue, Munakata, Motohiro, Sato, Daisuke, Kataoka, Yu, Kawamata, Ryota
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 22.09.2023; MDPI
• Subjects: barrier membrane; Bioengineering; bone graft displacement; Bone grafts; Bone-grafting; carbonate apatite; Collagen; Fibroblasts; Grafting; Grafts; Infections; Lactic acid; lateral approach; Maxillary sinus; Medical prognosis; Medical research; Medicine, Experimental; Membranes; Methods; Organic acids; Patients; Review boards; Risk factors; sinus augmentation; Sinuses; Sinusitis; Skin & tissue grafts; Substitute bone; Surgery; Japan
• ISSN: 2306-5354; 2306-5354
• DOI: 10.3390/bioengineering10101110

Maxillary sinus augmentation with a lateral approach (MSA) is a well-established treatment. In this prospective study, we evaluated risk factors for postoperative bone graft displacement and reported the clinical application of long-term resorbable L-lactic acid/-caprolactone (PLA/PCL) as a barrier membrane to cover the open window in the lateral wall in MSA. Twenty-four patients underwent MSA according to the relevant criteria; CT data obtained before and 1 week (1 w) and 5–6 months (5 m) post-MSA, bone height changes, bone height reduction rates at 1 w and 5 m post-MSA, bone graft displacement measurements, and risk factors were examined. All patients showed bone height increments (p < 0.005). However, no difference was observed between 1 w and 5 m post-MSA. Bone graft displacement was observed in eight patients; the reduction rate from 1 w to 5 m post-MSA was 8.38% ± 4.88%. Sex, septa, maxillary sinus floor–palatal bone distance, and maxillary sinus floor–maxillary ostium distance were associated with bone graft displacement (p < 0.05). The height from the maxillary sinus floor to the palatal bone and the sinus angle influenced the augmentation degree (p < 0.05). The PLA/PCL membrane is compared favorably with other membranes and may be useful as a barrier membrane for the MSA open window.