Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer

• Published in: The New England journal of medicine Vol. 380; no. 1; pp. 23 - 32
• Main Authors: Manson, JoAnn E, Cook, Nancy R, Lee, I-Min, Christen, William, Bassuk, Shari S, Mora, Samia, Gibson, Heike, Albert, Christine M, Gordon, David, Copeland, Trisha, D’Agostino, Denise, Friedenberg, Georgina, Ridge, Claire, Bubes, Vadim, Giovannucci, Edward L, Willett, Walter C, Buring, Julie E
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 03.01.2019
• Subjects: Age; Aged; Cancer; Cardiovascular disease; Cardiovascular diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - mortality; Cardiovascular Diseases - prevention & control; Cerebral infarction; Clinical trials; Death; Diabetes; Dietary supplements; Disease prevention; Drug dosages; Evidence-based medicine; Fatty acids; Fatty Acids, Omega-3 - adverse effects; Fatty Acids, Omega-3 - therapeutic use; FDA approval; Female; Fish oils; Follow-Up Studies; Health risk assessment; Heart attacks; Humans; Hypothesis testing; Incidence; Intervention; Investigations; Male; Middle Aged; Myocardial infarction; Neoplasms - epidemiology; Neoplasms - mortality; Neoplasms - prevention & control; Omega-3 fatty acids; Questionnaires; Stroke; Supplements; Treatment Failure; Vitamin D; Vitamin D3; Womens health; United States > US
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa1811403

This article reports the n−3 fatty acid portion of a randomized, placebo-controlled, two-by-two factorial trial of vitamin D and marine n−3 fatty acids in the primary prevention of cancer and cardiovascular disease. Fatty acids did not lead to a lower incidence of major cardiovascular events or cancer.