Staphylococcus spp. Causatives of Infections and Carrier of blaZ , femA , and mecA Genes Associated with Resistance

spp. have been associated with cases of healthcare associated infections due to their high incidence in isolates from the hospital environment and their ability to cause infections in immunocompromised patients; synthesize biofilms on medical instruments, in the case of negative coagulase species; a...

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Published inAntibiotics (Basel) Vol. 12; no. 4; p. 671
Main Authors Pimenta, Laryssa Ketelyn Lima, Rodrigues, Carolina Andrade, Filho, Arlindo Rodrigues Galvão, Coelho, Clarimar José, Goes, Viviane, Estrela, Mariely, de Souza, Priscila, Avelino, Melissa Ameloti Gomes, Vieira, José Daniel Gonçalves, Carneiro, Lilian
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 29.03.2023
MDPI
Subjects
Antibiotics
Biofilms
Chromosomes
Coagulase
FemA protein
Gene expression
Genes
hospital infections
Immunocompromised hosts
Intensive care
MecA protein
Medical equipment
Medical instruments
Mortality
Nosocomial infections
Oxacillin
Penicillin
penicillin G
Plasmids
qPCR
resistance
Staphylococcus
Brazil
hospital infections
qPCR
oxacillin
penicillin G
Staphylococcus
resistance
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Summary:spp. have been associated with cases of healthcare associated infections due to their high incidence in isolates from the hospital environment and their ability to cause infections in immunocompromised patients; synthesize biofilms on medical instruments, in the case of negative coagulase species; and change in genetic material, thus making it possible to disseminate genes that code for the acquisition of resistance mechanisms against the action of antibiotics. This study evaluated the presence of , , and chromosomal and plasmid genes of spp. using the qPCR technique. The results were associated with the phenotypic expression of resistance to oxacillin and penicillin G. We found that the chromosomal gene was present in a greater proportion in when compared with the other species analyzed, while the plasmid-borne gene was prevalent in the samples. The binary logistic regression performed to verify the association among the expression of the genes analyzed and the acquisition of resistance to oxacillin and penicillin G were not significant in any of the analyses, > 0.05.
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ISSN:2079-6382
2079-6382
DOI:10.3390/antibiotics12040671