Early impairment of synaptic plasticity in patients with Down's syndrome

We investigated synaptic plasticity in persons with Down’ syndrome (DS) and control subjects used paired associative stimulation (PAS) protocol, a paradigm capable of producing long-term potentiation (LTP)-like changes in the sensorimotor system. After PAS, patients showed less LTP-like plasticity c...

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Published inNeurobiology of aging Vol. 29; no. 8; pp. 1272 - 1275
Main Authors Battaglia, Fortunato, Quartarone, Angelo, Rizzo, Vincenzo, Ghilardi, Maria Felice, Di Rocco, Alessandro, Tortorella, Gaetano, Girlanda, Paolo
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.08.2008
Subjects
Adolescent
Cerebral Cortex - physiopathology
Down Syndrome - physiopathology
Down's syndrome
Female
Humans
Internal Medicine
Long-Term Potentiation
LTP
Male
Neurology
Neuronal Plasticity
Synaptic Transmission
Transcranial magnetic stimulation
LTP
Transcranial magnetic stimulation
TMS
Down's syndrome
DS
transcranial magnetic stimulation
long-term potentiation
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Summary:We investigated synaptic plasticity in persons with Down’ syndrome (DS) and control subjects used paired associative stimulation (PAS) protocol, a paradigm capable of producing long-term potentiation (LTP)-like changes in the sensorimotor system. After PAS, patients showed less LTP-like plasticity compared to control subjects. Abnormal motor cortex synaptic plasticity may play a role in the development of motor signs in DS.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0197-4580
1558-1497
1558-1497
DOI:10.1016/j.neurobiolaging.2007.02.025