Antioxidative Glutathione Peroxidase Activity of Selenoglutathione

Pep talk: Selenoglutathione (GSeH) and other peptides containing selenocysteine with an amino acid sequence of the glutathione peroxidase (GPx) active site are obtained in the oxidized form by solid‐phase peptide synthesis. Their GPx activity against hydrogen peroxide (see picture) reveals that GSeH...

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Published inAngewandte Chemie (International ed.) Vol. 50; no. 9; pp. 2125 - 2128
Main Authors Yoshida, Sari, Kumakura, Fumio, Komatsu, Itsuki, Arai, Kenta, Onuma, Yuko, Hojo, Hironobu, Singh, Beena G, Priyadarsini, K. Indira, Iwaoka, Michio
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 25.02.2011
WILEY-VCH Verlag
WILEY‐VCH Verlag
Wiley
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
antioxidants
Biocatalysis
Catalytic Domain
Chemistry
Chemistry, Multidisciplinary
enzyme catalysis
enzyme models
Glutathione - analogs & derivatives
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Oxidation-Reduction
peptides
Peptides - chemical synthesis
Peptides - chemistry
Physical Sciences
Science & Technology
selenium
Selenium - chemistry
Selenocysteine - metabolism
DISELENIDES
selenium
antioxidants
MIMICS
CHEMISTRY
enzyme catalysis
peptides
SELENOCYSTEINE
enzyme models
PHGPX
GPX
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Summary:Pep talk: Selenoglutathione (GSeH) and other peptides containing selenocysteine with an amino acid sequence of the glutathione peroxidase (GPx) active site are obtained in the oxidized form by solid‐phase peptide synthesis. Their GPx activity against hydrogen peroxide (see picture) reveals that GSeH has effective antioxidant activity in addition to the biological function of a glutathione analogue.
Bibliography:http://dx.doi.org/10.1002/anie.201006939
India-Japan Collaborative Science Programme - No. 08039221-000181
ArticleID:ANIE201006939
istex:DAD2A51A20DE29CE5EDD6E6C13C6924C800D0019
This work was supported by a Grant-in-Aid for Scientific Research (B) (No. 16350092) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the India-Japan Collaborative Science Programme (IJCSP; No. 08039221-000181).
ark:/67375/WNG-PG360LC5-K
Grant-in-Aid for Scientific Research - No. 16350092
Ministry of Education, Culture, Sports, Science, and Technology of Japan
This work was supported by a Grant‐in‐Aid for Scientific Research (B) (No. 16350092) from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the India–Japan Collaborative Science Programme (IJCSP; No. 08039221‐000181).
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201006939