Fluorescent Platinum Nanoclusters: Synthesis, Purification, Characterization, and Application to Bioimaging

Let your light shine: The atomically monodisperse Pt5 nanocluster has low cytotoxicity and a fluorescence quantum yield of 18 %. Furthermore, it can be used as a fluorescent probe for cellular imaging (see picture; gray sphere: Pt5 nanocluster; PAMAM (G4‐OH): fourth‐generation polyamidoamine dendrim...

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Published inAngewandte Chemie (International ed.) Vol. 50; no. 2; pp. 431 - 435
Main Authors Tanaka, Shin-Ichi, Miyazaki, Jun, Tiwari, Dhermendra K, Jin, Takashi, Inouye, Yasushi
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 10.01.2011
WILEY-VCH Verlag
WILEY‐VCH Verlag
Wiley Subscription Services, Inc
EditionInternational ed. in English
Subjects
cellular imaging
Dendrimers - chemistry
Dendrimers - toxicity
Fluorescent Dyes - chemistry
fluorescent probes
HeLa Cells
Humans
Metal Nanoparticles - chemistry
Metal Nanoparticles - toxicity
Microscopy, Confocal
Microscopy, Fluorescence
nanoclusters
platinum
Platinum - chemistry
Quantum Theory
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Summary:Let your light shine: The atomically monodisperse Pt5 nanocluster has low cytotoxicity and a fluorescence quantum yield of 18 %. Furthermore, it can be used as a fluorescent probe for cellular imaging (see picture; gray sphere: Pt5 nanocluster; PAMAM (G4‐OH): fourth‐generation polyamidoamine dendrimer; scale bar 20 μm).
Bibliography:http://dx.doi.org/10.1002/anie.201004907
ArticleID:ANIE201004907
ark:/67375/WNG-2LBJH126-C
This work is supported by the Global COE program, Osaka Univ. Y.I. gratefully acknowledges financial support by a Grant-in-Aid for Scientific Research No. 21360032 from the Ministry of Education, Culture, Sports, Science and Technology. We thank Dr. M. Murakami for ESI mass spectrometry, Dr. T. Fukumoto for ICP-mass spectrometry, and Prof. K. Namba and Dr. T. Kato for allowing us to use an ultracentrifugation system. We also thank Dr. T. Watanabe and Ms K. Yoshizawa for cell viability testing.
istex:D472424318D28F4C4A63AF3F17E971333D27EE13
Ministry of Education, Culture, Sports, Science and Technology - No. 21360032
This work is supported by the Global COE program, Osaka Univ. Y.I. gratefully acknowledges financial support by a Grant‐in‐Aid for Scientific Research No. 21360032 from the Ministry of Education, Culture, Sports, Science and Technology. We thank Dr. M. Murakami for ESI mass spectrometry, Dr. T. Fukumoto for ICP‐mass spectrometry, and Prof. K. Namba and Dr. T. Kato for allowing us to use an ultracentrifugation system. We also thank Dr. T. Watanabe and Ms K. Yoshizawa for cell viability testing.
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SourceType-Scholarly Journals-1
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201004907