Endothelin-1 release from mesenteric arteries of spontaneously hypertensive rats

Release of endothelin-1 (ET-1) from the mesenteric arteries of spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were measured by radioimmunoassay after purification using immunoaffinity column. The identity of ET-1 in perfusate was established using reversed-phase high-performance l...

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Bibliographic Details
Published inJournal of cardiovascular pharmacology Vol. 17 Suppl 7; p. S408
Main Authors Miyamori, I, Takeda, Y, Yoneda, T, Takeda, R
Format Journal Article
LanguageEnglish
Published United States 1991
Subjects
Aging - metabolism
Animals
Blood Pressure - physiology
Endothelins - metabolism
Heart Rate - physiology
Hypertension - metabolism
Mesenteric Arteries - metabolism
Rats
Rats, Inbred SHR
Rats, Inbred WKY
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Summary:Release of endothelin-1 (ET-1) from the mesenteric arteries of spontaneously hypertensive rats (SHR) and Wistar-Kyoto (WKY) rats were measured by radioimmunoassay after purification using immunoaffinity column. The identity of ET-1 in perfusate was established using reversed-phase high-performance liquid chromatography. The mesenteric arteries from 5- to 6- and 9- to 10-week-old SHR released a significantly higher level (mean +/- SEM) of ET-1 (32.8 +/- 2.8 and 47.5 +/- 4.1 pg/h, respectively) than WKY age-matched rats (23.4 +/- 2.1 and 34.8 +/- 3.7, respectively). There was an age-related increase in ET-1 release in both groups of rats. Though the SHR studied were in the hypertensive stage, the present results suggest that locally produced ET-1 may contribute to the development of hypertension independent of the plasma levels.
ISSN:0160-2446
DOI:10.1097/00005344-199100177-00115