Chemical Approaches to Controlling Intracellular Protein Degradation

Inactive. Recent advances have yielded many ways to study proteins by means of inactivation. Traditional methods of genetic knockout are complimented by newer techniques, including RNAi and small molecules that induce proteolysis (see scheme). Although seemingly in competition, these techniques each...

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Bibliographic Details
Published inChembiochem : a European journal of chemical biology Vol. 6; no. 1; pp. 40 - 46
Main Authors Schneekloth, John S. Jr, Crews, Craig M
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 01.01.2005
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
Animals
Benzoquinones
bioorganic chemistry
chemical genetics
Gene Silencing
Lactams, Macrocyclic
Protein Denaturation
protein modifications
Protein Processing, Post-Translational
Proteins - metabolism
Quinones - chemistry
Recombinant Proteins - genetics
RNA
RNA, Small Interfering - physiology
signal transduction
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Summary:Inactive. Recent advances have yielded many ways to study proteins by means of inactivation. Traditional methods of genetic knockout are complimented by newer techniques, including RNAi and small molecules that induce proteolysis (see scheme). Although seemingly in competition, these techniques each offer solutions to specific problems in proteomic analysis.
Bibliography:http://dx.doi.org/10.1002/cbic.200400274
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ArticleID:CBIC200400274
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-2
ISSN:1439-4227
1439-7633
DOI:10.1002/cbic.200400274