Alterations in immunodominance of Streptococcus mutans AgI/II: Lessons learned from immunomodulatory antibodies

• Published in: Vaccine Vol. 32; no. 3; pp. 375 - 382
• Main Authors: Robinette, Rebekah A, Heim, Kyle P, Oli, Monika W, Crowley, Paula J, McArthur, William P, Brady, L. Jeannine
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 09.01.2014; Elsevier
• Subjects: Allergy and Immunology; Animals; Antibodies, Bacterial - immunology; Antigens, Bacterial - administration & dosage; Antigens, Bacterial - genetics; Antigens, Bacterial - immunology; Applied microbiology; Bacteriology; Biological and medical sciences; Epitopes, T-Lymphocyte - immunology; Female; Fundamental and applied biological sciences. Psychology; Immune complex; Immunodominance; Immunodominant Epitopes - administration & dosage; Immunodominant Epitopes - genetics; Immunodominant Epitopes - immunology; Mice; Mice, Inbred BALB C; Microbiology; Miscellaneous; Monoclonal antibody; Protein Structure, Tertiary; Streptococcal Vaccines - administration & dosage; Streptococcal Vaccines - genetics; Streptococcal Vaccines - immunology; Streptococcus; Streptococcus mutans; Streptococcus mutans - immunology; Vaccine design; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Streptococcus; Vaccine design; Monoclonal antibody; Immunodominance; Immune complex; Streptococcaceae; Bacteria; Micrococcales; Vaccine; Streptococcus mutans
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2013.11.023

Highlights • Streptococcus mutans adhesin AgI/II elicits adherence inhibiting antibodies. • We utilize truncated proteins to identify targets of relevant antibodies. • Putative amino-terminal T cell epitopes impact formation of adherence-inhibiting antibodies. • The C-terminus was identified as a new target of adherence-inhibiting antibodies. • An intramolecular interaction appears to dampen the adherence inhibiting immune response.