Difference in kinetics between the distal and proximal parts of the canine parietal cell mass in response to histamine
Dogs provided with one denervated gastric pouch in the distal part of the corpus fundus and another of equal size in the proximal part, were studied during histamine stimulation. Dose-response curves were determined for acid output and mucosal blood flow, which was measured with the Neutral Red tech...
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Published in | The Journal of physiology Vol. 335; no. 1; pp. 113 - 121 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
England
The Physiological Society
01.02.1983
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Subjects | |
Online Access | Get full text |
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Summary: | Dogs provided with one denervated gastric pouch in the distal part of the corpus fundus and another of equal size in the proximal
part, were studied during histamine stimulation. Dose-response curves were determined for acid output and mucosal blood flow,
which was measured with the Neutral Red technique. Maximum acid output was significantly higher for the distal (mean 234.0
mumol min-1) than for the proximal pouch (120.0 mumol min-1). ED50 for acid output was significantly higher for the distal
(105.0 micrograms kg-1 h-1 of histamine) than for the proximal pouch (57.0 micrograms kg-1 h-1). ED50 for blood flow did not
differ significantly between the distal (40.5 micrograms kg-1 h-1) and the proximal pouch (29.0 micrograms kg-1 h-1). For
both pouches ED50 for blood flow was significantly lower than that for simultaneous acid output. This indicated that the rise
in blood flow precedes that in acid output. Regression analysis showed a significantly higher ratio between maximum mucosal
blood flow and maximum acid output for the distal (0.30 ml mumol-1) than for the proximal pouch (0.15 ml mumol-1). The finding
that ED50 for acid output in response to histamine was lower for the proximal pouch is contrary to earlier results obtained
with pentagastrin, which showed that ED50 was lower for the distal pouch. There is no valid explanation for these differences
in ED50 between the pouches, but a difference at receptor level could be hypothesized. The difference in maximum acid output
between the two pouches is explained by the known difference between distal and proximal parts in volume fraction of the parietal
cells. The possibility that these differences in acid production depend on dissimilarities in mucosal blood flow can be excluded. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0022-3751 1469-7793 |
DOI: | 10.1113/jphysiol.1983.sp014523 |