Stability and Shape of Hepatitis B Virus Capsids In Vacuo

Viruses at a glance: Ion mobility mass spectrometry allows the identification and differentiation of states in a viral assembly not only by mass but also by conformation. This approach has been used to obtain a biophysical characterization of the hepatitis B virus capsids, and has shown that of its...

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Published inAngewandte Chemie (International ed.) Vol. 47; no. 33; pp. 6247 - 6251
Main Authors Uetrecht, Charlotte, Versluis, Cees, Watts, Norman R, Wingfield, Paul T, Steven, Alasdair C, Heck, Albert J.R
Format Journal Article
LanguageEnglish
Published Weinheim Wiley-VCH Verlag 01.01.2008
WILEY-VCH Verlag
WILEY‐VCH Verlag
Subjects
analytical methods
Capsid - chemistry
Capsid - ultrastructure
Capsid Proteins - chemistry
Capsid Proteins - ultrastructure
conformational analysis
Hepatitis B virus - chemistry
Hepatitis B virus - ultrastructure
ion mobility
mass spectrometry
Mass Spectrometry - methods
Protein Conformation
Vacuum
viruses
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Summary:Viruses at a glance: Ion mobility mass spectrometry allows the identification and differentiation of states in a viral assembly not only by mass but also by conformation. This approach has been used to obtain a biophysical characterization of the hepatitis B virus capsids, and has shown that of its two distinct icosahedral geometries, the spherical capsid structure is preserved in vacuo (see picture).
Bibliography:http://dx.doi.org/10.1002/anie.200802410
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ArticleID:ANIE200802410
This research was supported by the Netherlands Proteomics Centre and the NIAMS Intramural Research Program of the NIH.
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ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200802410