Interictal magnetic signals in new-onset Rolandic epilepsy may help with timing of treatment selection

• Published in: Epilepsia open Vol. 9; no. 1; pp. 368 - 379
• Main Authors: Xu, Fengyuan, Li, Yihan, Wang, Yingfan, Wang, Siyi, Sun, Fangling, Wang, Xiaoshan
• Format: Journal Article
• Language: English
• Published: United States John Wiley & Sons, Inc 01.02.2024; John Wiley and Sons Inc; Wiley
• Subjects: Age; BECTS; CECTS; Children & youth; Convulsions & seizures; Epilepsy; Females; Magnetic resonance imaging; MEG; Neuropsychology; Original; Parents & parenting; Patients; SeLECTS; CECTS; SeLECTS; BECTS; MEG
• ISSN: 2470-9239; 2470-9239
• DOI: 10.1002/epi4.12884

With research progress on Rolandic epilepsy (RE), its "benign" nature has been phased out. Clinicians are exhibiting an increasing tendency toward a more assertive treatment approach for RE. Nonetheless, in clinical practice, delayed treatment remains common because of the "self-limiting" nature of RE. Therefore, this study aimed to identify an imaging marker to aid treatment decisions and select a more appropriate time for initiating therapy for RE. We followed up with children newly diagnosed with RE, classified them into medicated and non-medicated groups according to the follow-up results, and compared them with matched healthy controls. Before beginning follow-up visits, interictal magnetic data were collected using magnetoencephalography in treatment-naïve recently diagnosed patients. The spectral power of the whole brain during initial diagnosis was determined using minimum normative estimation combined with the Welch technique. A difference was observed in the magnetic source intensity within the left caudal anterior cingulate and precentral and postcentral gyri in the delta band between the medicated and non-medicated groups. The results revealed good discriminatory ability within the receiver operator characteristic curve. In the medicated group, there was a specific change in the frontotemporal magnetic source intensity, which shifted from high to low frequencies, compared with the healthy control group. The intensity of the precentral gyrus magnetic source within the delta band showed good specificity. Considering the rigor of initial treatment, the intensity of the precentral gyrus magnetic source can provide some help as an imaging marker for initial RE treatment, particularly for the timing of treatment initiation.