Dietary Marine Hydrolysate Improves Memory Performance and Social Behavior through Gut Microbiota Remodeling during Aging

• Published in: Foods Vol. 12; no. 23; p. 4199
• Main Authors: Mougin, Camille, Chataigner, Mathilde, Lucas, Céline, Leyrolle, Quentin, Pallet, Véronique, Layé, Sophie, Bouvret, Elodie, Dinel, Anne-Laure, Joffre, Corinne
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.11.2023; MDPI
• Subjects: Aging; Animal behavior; Animal cognition; Anxiety; Behavior; Circadian rhythms; Cognitive ability; cognitive decline; Corticosterone; Diet; Electron transport; Ethylenediaminetetraacetic acid; Fish; Gene expression; Genes; Hydrolysates; Intestinal microflora; Life Sciences; Long term memory; low-molecular-weight peptides; Memory; Metabolism; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Modulation; n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs); Neuroprotection; Nutrition; Older people; Peptides; Quality of life; Short term memory; Social aspects; Social behavior; Social factors; Spatial memory; stress response; France; low-molecular-weight peptides; memory; stress response; n-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs); social behavior; marine functional food; aging; cognitive decline; gut microbiota
• ISSN: 2304-8158; 2304-8158
• DOI: 10.3390/foods12234199

Aging is characterized by a decline in social behavior and cognitive functions leading to a decrease in life quality. In a previous study, we show that a fish hydrolysate supplementation prevents age-related decline in spatial short-term memory and long-term memory and anxiety-like behavior and improves the stress response in aged mice. The aim of this study was to determine the effects of a fish hydrolysate enriched with EPA/DHA or not on the cognitive ability and social interaction during aging and the biological mechanisms involved. We showed for the first time that a fish hydrolysate enriched with EPA/DHA or not improved memory performance and preference for social novelty that were diminished by aging. These changes were associated with the modulation of the gut microbiota, normalization of corticosterone, and modulation of the expression of genes involved in the mitochondrial respiratory chain, circadian clock, neuroprotection, and antioxidant activity. Thus, these changes may contribute to the observed improvements in social behavior and memory and reinforced the innovative character of fish hydrolysate in the prevention of age-related impairments.