Improving printability of a thermoresponsive hydrogel biomaterial ink by nanoclay addition

As a promising biofabrication technology, extrusion-based bioprinting has gained significant attention in the last decade and major advances have been made in the development of bioinks. However, suitable synthetic and stimuli-responsive bioinks are underrepresented in this context. In this work, we...

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Bibliographic Details
Published inJournal of materials science Vol. 56; no. 1; pp. 691 - 705
Main Authors Hu, Chen, Hahn, Lukas, Yang, Mengshi, Altmann, Alexander, Stahlhut, Philipp, Groll, Jürgen, Luxenhofer, Robert
Format Journal Article
LanguageEnglish
Published New York Springer US 2021
Springer
Springer Nature B.V
Subjects
3D printing
Bioengineering
Biological products
Biomedical materials
Block copolymers
Characterization and Evaluation of Materials
Chemistry and Materials Science
Classical Mechanics
Clay
Crystallography and Scattering Methods
Extrusion
Hybrid systems
Hydrogels
Materials for Life Sciences
Materials Science
Polymer Sciences
Printing-ink
Properties (attributes)
Recovery
Shear thinning (liquids)
Solid Mechanics
Storage modulus
Three dimensional printing
Yield stress
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Summary:As a promising biofabrication technology, extrusion-based bioprinting has gained significant attention in the last decade and major advances have been made in the development of bioinks. However, suitable synthetic and stimuli-responsive bioinks are underrepresented in this context. In this work, we described a hybrid system of nanoclay Laponite XLG and thermoresponsive block copolymer poly(2-methyl-2-oxazoline)- b -poly(2- n -propyl-2-oxazine) (PMeOx- b -PnPrOzi) as a novel biomaterial ink and discussed its critical properties relevant for extrusion-based bioprinting, including viscoelastic properties and printability. The hybrid hydrogel retains the thermogelling properties but is strengthened by the added clay (over 5 kPa of storage modulus and 240 Pa of yield stress). Importantly, the shear-thinning character is further enhanced, which, in combination with very rapid viscosity recovery (~ 1 s) and structure recovery (~ 10 s), is highly beneficial for extrusion-based 3D printing. Accordingly, various 3D patterns could be printed with markedly enhanced resolution and shape fidelity compared to the biomaterial ink without added clay. Graphic abstract
ISSN:0022-2461
1573-4803
DOI:10.1007/s10853-020-05190-5