Administration of Perilla Oil Coated with Calshell Increases Glucagon-Like Peptide Secretion

• Published in: Biological & pharmaceutical bulletin Vol. 31; no. 5; pp. 1021 - 1023
• Main Authors: Adachi, Tetsuya, Yanaka, Hiroyuki, Kanai, Hitoshi, Nozaki, Mayu, Takahara, Yoshiyuki, Tsuda, Mariko, Jonouchi, Tatsuya, Tsuda, Kinsuke, Hirasawa, Akira, Tsujimoto, Gozoh
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 01.05.2008; Japan Science and Technology Agency
• Subjects: alpha-Linolenic Acid - administration & dosage; alpha-Linolenic Acid - metabolism; alpha-Linolenic Acid - pharmacology; Animals; Calshell; Drug Carriers - chemistry; Drug Delivery Systems; Gastric Juice - drug effects; Gastric Juice - metabolism; Glucagon-Like Peptide 1 - biosynthesis; glucagon-like peptide-1; insulin; Insulin - blood; Intestinal Mucosa - metabolism; Male; Mice; Mice, Inbred C57BL; mouse; perilla oil; Plant Oils - administration & dosage; Plant Oils - metabolism; Plant Oils - pharmacology; Powders
• ISSN: 0918-6158; 1347-5215
• DOI: 10.1248/bpb.31.1021

Recently, we found that unsaturated long-chain fatty acids (such as α-linolenic acid) promote the secretion of glucagon-like peptide-1 (GLP-1) via G protein-coupled receptor GPR120, which is expressed predominantly in the colon. In order to ensure that the triglycerides or free fatty acids, such as α-linolenic acid, reach the distal intestinal tract effectively, we developed a Calshell technique. Following single treatment of Calshell perilla oil powder, the GLP-1 secretion level was significantly higher than following vehicle treatment, 120 min after treatment. Next, we examined the effects of long-term Calshell perilla oil powder treatment on GLP-1 secretion. Plasma GLP-1 level of Calshell perilla oil powder treatment was significantly higher than of vehicle treatment for 1, 14, 28 and 56 d. We thereby demonstrated for the first time the utility of Calshell oil powder treatment for effective and sustainable GLP-1 secretion. The Calshell technique is apparently useful as a drug delivery system, since Calshell unsaturated oil powder is protected from gastric acid, reaches enteroendocrine cells in the gastrointestinal tract, and then induces effective incretin secretion.