Chromone Derivatives and Other Constituents from Cultures of the Marine Sponge-Associated Fungus Penicillium erubescens KUFA0220 and Their Antibacterial Activity

• Published in: Marine drugs Vol. 16; no. 8; p. 289
• Main Authors: Kumla, Decha, Pereira, José A, Dethoup, Tida, Gales, Luis, Freitas-Silva, Joana, Costa, Paulo M, Lee, Michael, Silva, Artur M S, Sekeroglu, Nazim, Pinto, Madalena M M, Kijjoa, Anake
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 20.08.2018; MDPI
• Subjects: Animals; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Aquatic Organisms - chemistry; Aspergillaceae; Bacteria; Bacteria - drug effects; Carboxylic acids; chromone derivatives; Chromones - chemistry; Chromones - pharmacology; Derivatives; Dimers; Ergosterol; Fungi; Fungi - chemistry; GKK 1032B; Gram-negative bacteria; Gram-positive bacteria; Marine invertebrates; marine sponge-associated fungus; Methicillin; Microbiological strains; Multidrug resistance; Neopetrosia sp; Penicillium; Penicillium - chemistry; Penicillium erubescens; Porifera - chemistry; pyranochromone; spirofuranochromone; Staphylococcus aureus; antibacterial activity; spirofuranochromone; GKK 1032B; Aspergillaceae; Neopetrosia sp; marine sponge-associated fungus; Penicillium erubescens; pyranochromone; chromone derivatives
• ISSN: 1660-3397; 1660-3397
• DOI: 10.3390/md16080289

A previously unreported chromene derivative, 1-hydroxy-12-methoxycitromycin ( ), and four previously undescribed chromone derivatives, including pyanochromone ( ), spirofuranochromone ( ), 7-hydroxy-6-methoxy-4-oxo-3-[(1 )-3-oxobut-1-en-1-yl]-4 -chromene-5-carboxylic acid ( ), a pyranochromone dimer ( ) were isolated, together with thirteen known compounds: β-sitostenone, ergosterol 5,8-endoperoxide, citromycin ( ), 12-methoxycitromycin ( ), myxotrichin D ( ), 12-methoxycitromycetin ( ), anhydrofulvic acid ( ), myxotrichin C ( ), penialidin D ( ), penialidin F ( ), SPF-3059-30 ( ), GKK1032B ( ) and secalonic acid A ( ), from cultures of the marine sponge- associated fungus KUFA0220. Compounds ⁻ , , , , ⁻ , were tested for their antibacterial activity against Gram-positive and Gram-negative reference and multidrug-resistant strains isolated from the environment. Only exhibited an in vitro growth inhibition of all Gram-positive bacteria whereas showed growth inhibition of methicillin-resistant (MRSA). None of the compounds were active against Gram-negative bacteria tested.