Persistent olmesartan-based blood pressure-lowering effects on morning hypertension in Asians: the HONEST study

• Published in: Hypertension research Vol. 39; no. 5; pp. 334 - 341
• Main Authors: Kario, Kazuomi, Saito, Ikuo, Kushiro, Toshio, Teramukai, Satoshi, Yaginuma, Mai, Mori, Yoshihiro, Okuda, Yasuyuki, Kobayashi, Fumiaki, Shimada, Kazuyuki
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.05.2016
• Subjects: Aged; Antihypertensive Agents - pharmacology; Antihypertensive Agents - therapeutic use; Asian People; Blood Pressure - drug effects; Blood Pressure Monitoring, Ambulatory; Female; Humans; Hypertension - drug therapy; Imidazoles - pharmacology; Imidazoles - therapeutic use; Male; Middle Aged; Original; Prospective Studies; Tetrazoles - pharmacology; Tetrazoles - therapeutic use; Treatment Outcome
• ISSN: 0916-9636; 1348-4214
• DOI: 10.1038/hr.2015.148

Using data from the large-scale HONEST (Home blood pressure measurement with Olmesartan Naive patients to Establish Standard Target blood pressure) study, we investigated the characteristics of the effects of olmesartan-based treatment on morning hypertension in Asian hypertensive patients. Specifically, we investigated the relationship between baseline blood pressure (BP) and BP reduction after 16 weeks by linear regression analyses; determinants of BP reduction were also investigated. For both morning home BP (MHBP) and clinic BP (CBP), reduced systolic BP (SBP) after 16 weeks was associated with baseline SBP (P<0.001). The slope of the regression lines was similar for morning home SBP (MHSBP) (-0.744) and clinic SBP (-0.735). Although sex, concomitant diabetes mellitus and concomitant hepatic disease significantly influence the relationship between BP reduction and baseline BP for MHSBP, none were deemed clinically relevant. In conclusion, olmesartan-based treatment robustly reduced baseline high MHBP, similar to CBP, and the effect was associated with baseline BP but unaffected by patient background factors.