Negative mpMRI Rules Out Extra-Prostatic Extension in Prostate Cancer before Robot-Assisted Radical Prostatectomy

• Published in: Diagnostics (Basel) Vol. 12; no. 5; p. 1057
• Main Authors: Dinneen, Eoin, Allen, Clare, Strange, Tom, Heffernan-Ho, Daniel, Banjeglav, Jelena, Lindsay, Jamie, Mulligan, John-Patrick, Briggs, Tim, Nathan, Senthil, Sridhar, Ashwin, Grierson, Jack, Haider, Aiman, Panayi, Christos, Patel, Dominic, Freeman, Alex, Aning, Jonathan, Persad, Raj, Ahmad, Imran, Dutto, Lorenzo, Oakley, Neil, Ambrosi, Alessandro, Parry, Tom, Kasivisvanathan, Veeru, Giganti, Francesco, Shaw, Greg, Punwani, Shonit
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 23.04.2022; MDPI
• Subjects: Accuracy; Biopsy; extra-prostatic extension; Magnetic resonance imaging; nerve-sparing; Pathology; Prostate cancer; radical prostatectomy; staging; nerve-sparing; diagnostic accuracy; magnetic resonance imaging; prostate cancer; radical prostatectomy; extra-prostatic extension; staging
• ISSN: 2075-4418; 2075-4418
• DOI: 10.3390/diagnostics12051057

The accuracy of multi-parametric MRI (mpMRI) in the pre-operative staging of prostate cancer (PCa) remains controversial. The purpose of this study was to evaluate the ability of mpMRI to accurately predict PCa extra-prostatic extension (EPE) on a side-specific basis using a risk-stratified 5-point Likert scale. This study also aimed to assess the influence of mpMRI scan quality on diagnostic accuracy. We included 124 men who underwent robot-assisted RP (RARP) as part of the NeuroSAFE PROOF study at our centre. Three radiologists retrospectively reviewed mpMRI blinded to RP pathology and assigned a Likert score (1-5) for EPE on each side of the prostate. Each scan was also ascribed a Prostate Imaging Quality (PI-QUAL) score for assessing the quality of the mpMRI scan, where 1 represents the poorest and 5 represents the best diagnostic quality. Diagnostic performance is presented for the binary classification of EPE, including 95% confidence intervals and the area under the receiver operating characteristic curve (AUC). A total of 231 lobes from 121 men (mean age 56.9 years) were evaluated. Of these, 39 men (32.2%), or 43 lobes (18.6%), had EPE. A Likert score ≥3 had a sensitivity (SE), specificity (SP), NPV, and PPV of 90.4%, 52.3%, 96%, and 29.9%, respectively, and the AUC was 0.82 (95% CI: 0.77-0.86). The AUC was 0.76 (95% CI: 0.64-0.88), 0.78 (0.72-0.84), and 0.92 (0.88-0.96) for biparametric scans, PI-QUAL 1-3, and PI-QUAL 4-5 scans, respectively. MRI can be used effectively by genitourinary radiologists to rule out EPE and help inform surgical planning for men undergoing RARP. EPE prediction was more reliable when the MRI scan was (a) multi-parametric and (b) of a higher image quality according to the PI-QUAL scoring system.