Key Determinants of Immune-Mediated Adverse Reactions to Oncology Drugs

• Published in: Cancers Vol. 15; no. 23; p. 5622
• Main Authors: Zhou, Yihan, Ding, Shan
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.11.2023
• Subjects: Antibodies; Biomarkers; cancer immunotherapy; Cancer therapies; Cell death; Chemotherapy; Complications and side effects; Drug dosages; Epidemiology; Hypothyroidism; Immune checkpoint inhibitors; immune checkpoint inhibitors (ICIs); Immune response; immune-mediated adverse drug events (imADEs); immune-mediated adverse drug reactions (imADRs); Immunosuppressive agents; Immunotherapy; Inflammatory bowel disease; Ipilimumab; Melanoma; Monoclonal antibodies; Patients; Pharmacovigilance; Radiation therapy; Side effects; Toxicity; Tumors; Viral antibodies; immune-mediated adverse drug events (imADEs); immune-mediated adverse drug reactions (imADRs); immune checkpoint inhibitors (ICIs); cancer immunotherapy
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers15235622

To overcome the epidemiological severity of cancer, developing effective treatments is urgently required. In response, immune checkpoint inhibitors (ICIs) have been revealed as a promising resolution for treatment-resistant cancers across the world. Yet, they have both advantages and disadvantages, bringing therapeutic benefits while simultaneously inducing toxicity, and in particular, immune-mediated adverse drug reactions (imADRs), to the human body. These imADRs can be pathogenic and sometimes lethal, hampering health prediction and monitoring following the provision of ICI treatment. Therefore, it is necessary to collectively identify the determinant factors that contribute to these imADRs induced by ICIs. This article evaluated treatment-, tumor-, and patient-related determinants, and indicated a research gap for future investigations on the pathogenic mechanism of imADRs and translational conversion of determinants into clinical biomarkers to aid pharmacovigilance and cancer therapies.