FAM64A Promotes Osteosarcoma Cell Growth and Metastasis and Is Mediated by miR-493

Aberrant expression of FAM64A was correlated with cell proliferation in various cancer types. We examined the expression of FAM64A and the upstream gene miR-493 in OS. The functions of miR-493 were revealed through extensive experiments. We found an increase of FAM64A gene and protein in OS tissues....

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Published inJournal of oncology Vol. 2020; no. 2020; pp. 1 - 13
Main Authors Yan, Jun, Wang, Jingwen, Yin, Zhiqi, Gao, Qiang, Zhou, Chunlei, Jiang, Ying, Mu, Hong
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2020
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Binding sites
Bone cancer
Cell cycle
Cell growth
Gene expression
Medical prognosis
Metastasis
MicroRNAs
Non-Hodgkin's lymphomas
Operating systems
Osteosarcoma
Sarcoma
Scientific equipment and supplies industry
Statistical analysis
United States
China
United States > US
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Summary:Aberrant expression of FAM64A was correlated with cell proliferation in various cancer types. We examined the expression of FAM64A and the upstream gene miR-493 in OS. The functions of miR-493 were revealed through extensive experiments. We found an increase of FAM64A gene and protein in OS tissues. Overexpression of FAM64A resulted in promoting tumor proliferation, migration, and invasion. The miR-493 targeted and negatively regulated FAM64A. Our data showed that upregulation of FAM64A in OS correlated with poor prognosis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
Academic Editor: Michelle Ghert
ISSN:1687-8450
1687-8450
1687-8469
DOI:10.1155/2020/2518297