Pathogenic and protective role of macrophages in kidney disease

• Published in: American journal of physiology. Renal physiology Vol. 305; no. 1; pp. F3 - F11
• Main Authors: Cao, Qi, Wang, Yiping, Harris, David C. H.
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.07.2013
• Subjects: Animals; Cells; Cellular Microenvironment; Disease Models, Animal; Genotype & phenotype; Homeostasis; Humans; Kidney - immunology; Kidney - pathology; Kidney diseases; Kidney Diseases - immunology; Kidney Diseases - pathology; Kidney Diseases - prevention & control; Macrophages - immunology; Macrophages - pathology; Phenotype; Reviews; Tissues; kidney disease; macrophages; cell therapy

Macrophages (MΦ) are located throughout kidney tissue, where they play important roles in homeostasis, surveillance, tolerance, and cytoprotection. MΦ are highly heterogeneous cells and exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease typ...