Pathogenic and protective role of macrophages in kidney disease

Macrophages (MΦ) are located throughout kidney tissue, where they play important roles in homeostasis, surveillance, tolerance, and cytoprotection. MΦ are highly heterogeneous cells and exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease typ...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of physiology. Renal physiology Vol. 305; no. 1; pp. F3 - F11
Main Authors Cao, Qi, Wang, Yiping, Harris, David C. H.
Format Journal Article
LanguageEnglish
Published United States American Physiological Society 01.07.2013
Subjects
Animals
Cells
Cellular Microenvironment
Disease Models, Animal
Genotype & phenotype
Homeostasis
Humans
Kidney - immunology
Kidney - pathology
Kidney diseases
Kidney Diseases - immunology
Kidney Diseases - pathology
Kidney Diseases - prevention & control
Macrophages - immunology
Macrophages - pathology
Phenotype
Reviews
Tissues
kidney disease
macrophages
cell therapy
Online AccessGet full text

Cover

More Information
Summary:Macrophages (MΦ) are located throughout kidney tissue, where they play important roles in homeostasis, surveillance, tolerance, and cytoprotection. MΦ are highly heterogeneous cells and exhibit distinct phenotypic and functional characteristics depending on their microenvironment and the disease type and stage. Recent studies have identified a dual role for MΦ in several murine models of kidney disease. In this review, we discuss the pathogenic and protective roles of the various MΦ subsets in experimental and human kidney diseases and summarize current progress toward the therapeutic use of MΦ in kidney diseases.
Bibliography:SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 14
ObjectType-Article-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1931-857X
1522-1466
1522-1466
DOI:10.1152/ajprenal.00122.2013