Antipyretic, Analgesic and Muscle Relaxant Activities of Pueraria Isoflavonoids and Their Metabolites From Pueraria lobata Ohwi—a Traditional Chinese Drug

We evaluated the antipyretic, analgesic, and muscle relaxant activities of Pueraria isoflavonoids and their metabolites in mice. The glycosides daidzin and genistin significantly reduced fever induced by lipopolysaccharide (LPS). Their metabolites, daidzein and p-ethylphenol, also significantly redu...

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Published inBiological & pharmaceutical bulletin Vol. 28; no. 7; pp. 1224 - 1228
Main Authors Yasuda, Takaaki, Endo, Miwa, Kon-no, Toshiyuki, Kato, Tomoko, Mitsuzuka, Mariko, Ohsawa, Keisuke
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.07.2005
Japan Science and Technology Agency
Subjects
analgesic activity
Analgesics - pharmacology
Analgesics, Non-Narcotic - pharmacology
Animals
antipyretic activity
Flavonoids - chemistry
isoflavonoid
metabolite
Mice
muscle relaxant activity
Parasympatholytics - pharmacology
Pueraria - chemistry
Pueraria lobata
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Summary:We evaluated the antipyretic, analgesic, and muscle relaxant activities of Pueraria isoflavonoids and their metabolites in mice. The glycosides daidzin and genistin significantly reduced fever induced by lipopolysaccharide (LPS). Their metabolites, daidzein and p-ethylphenol, also significantly reduced fever induced by LPS. In addition, daidzin, daidzein, dihydrodaidzein, and p-ethylphenol showed analgesic activity as assessed by the acetic acid-induced writhing test. Furthermore, equol and p-ethylphenol showed muscle relaxant activity in the rotarod and horizontal wire test. These results suggest that these compounds play a major role in the therapeutic activity of Pueraria isoflavonoids.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.28.1224