Diagnostic Value of Neutrophil-Lymphocyte Ratio for Predicting the Severity of Acute Pancreatitis: A Meta-Analysis

• Published in: Disease markers Vol. 2020; no. 2020; pp. 1 - 9
• Main Authors: Zhang, Wenlong, Bao, Huarui, He, Yuanyuan, Kong, Weihao, Wang, Xingyu
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc
• Subjects: Analysis; Area Under Curve; Bivariate analysis; Case-Control Studies; Cases (containers); Diagnostic systems; Disease; Etiology; Humans; Leukocyte Count; Likelihood ratio; Lymphocytes; Lymphocytes - immunology; Lymphocytes - pathology; Meta-analysis; Neutrophils; Neutrophils - immunology; Neutrophils - pathology; Pancreatitis; Pancreatitis - diagnosis; Pancreatitis - immunology; Pancreatitis - pathology; Prognosis; Quality; Review; ROC Curve; Sensitivity and Specificity; Severity of Illness Index; Studies; China; Turkey; United Kingdom > UK; United States > US
• ISSN: 0278-0240; 1875-8630; 1875-8630
• DOI: 10.1155/2020/9731854

Background. Acute pancreatitis (AP) is a life-threatening disease caused by a variety of factors, and once it progresses to severe acute pancreatitis, the prognosis is poor. The purpose of this study was to investigate the diagnostic value of the neutrophil-lymphocyte ratio (NLR) for predicting the severity of acute pancreatitis. Materials and Methods. We searched the databases of PubMed, EMBASE, Web of Science, and Cochrane Library to identify eligible studies using the NLR to predict the severity of AP. The sensitivity (SEN), specificity (SPE), negative likelihood ratio (NLR), positive likelihood ratio (PLR), diagnostic odds ratio (DOR), and area under the receiver operating characteristic curve (AUC) were combined using a bivariate mixed model. Results. A total of 10 articles containing 394 cases and 1319 controls were included in the study. The combined SEN, SPE, NLR, PLR, DOR, and AUC are 79% (73%-84%), 71% (59%-80%), 0.30 (0.21-0.41), 2.7 (1.8-4.0), 9 (5-18), and 0.82 (0.78-0.85), respectively. Conclusions. NLR has a moderately high diagnostic value in predicting the severity of acute pancreatitis.