Effect of Globin Digests on Physical Fatigue in Mice

Globin digest (GD) inhibits dietary hypertriglyceridemia; however, its effects on physical fatigue remain unknown. Therefore, this study aimed to investigate the potential anti-fatigue effects of GD. Repeated administration of GD and valine (Val)-Val-tyrosine (Tyr)-proline (Pro), a component of GD,...

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Bibliographic Details
Published inBiological & pharmaceutical bulletin Vol. 46; no. 7; pp. 1027 - 1030
Main Authors Nakagawasai, Osamu, Yamada, Kotaro, Takahashi, Kohei, Oshima, Yuko, Hayasaka, Sena, Shoji, Kazuaki, Nemoto, Wataru, Tan-No, Koichi
Format Journal Article
LanguageEnglish
Published Japan The Pharmaceutical Society of Japan 01.07.2023
Japan Science and Technology Agency
Subjects
AMP-activated protein kinase
AMP-activated protein kinase (AMPK)
anti-fatigue effect
Fatigue
Hypertriglyceridemia
Lactic acid
Locomotion
physical fatigue
Soleus muscle
Valine
anti-fatigue effect
AMP-activated protein kinase (AMPK)
physical fatigue
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Summary:Globin digest (GD) inhibits dietary hypertriglyceridemia; however, its effects on physical fatigue remain unknown. Therefore, this study aimed to investigate the potential anti-fatigue effects of GD. Repeated administration of GD and valine (Val)-Val-tyrosine (Tyr)-proline (Pro), a component of GD, for five days prevented the forced walking-induced decrease in locomotion. Furthermore, GD treatment reversed the forced walking-induced increase in blood lactate levels in mice and increased phosphorylated AMP-activated protein kinase (p-AMPK) in the soleus muscle, suggesting that the anti-fatigue effect of GD involves AMPK activation in the soleus muscle through reduced blood lactate.
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ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.b23-00193