Remimazolam decreased the incidence of early postoperative nausea and vomiting compared to desflurane after laparoscopic gynecological surgery

• Published in: Journal of anesthesia Vol. 36; no. 2; pp. 265 - 269
• Main Authors: Hari, Yuki, Satomi, Shiho, Murakami, Chiaki, Narasaki, Soshi, Morio, Atsushi, Kato, Takahiro, Tsutsumi, Yasuo M., Kakuta, Nami, Tanaka, Katsuya
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 01.04.2022; Springer
• Subjects: Anesthesia; Anesthesiology; Antiemetics - therapeutic use; Benzodiazepines; Comparative analysis; Critical Care Medicine; Desflurane; Double-Blind Method; Emergency Medicine; Female; Gynecologic Surgical Procedures - adverse effects; Humans; Incidence; Intensive; Laparoscopic surgery; Laparoscopy; Laparoscopy - adverse effects; Medicine; Medicine & Public Health; Nausea; Original Article; Pain Medicine; Postoperative Nausea and Vomiting - epidemiology; Postoperative Nausea and Vomiting - prevention & control; Prospective Studies; Remifentanil; Japan; General anesthesia; Remimazolam; PONV
• ISSN: 0913-8668; 1438-8359
• DOI: 10.1007/s00540-022-03041-y

Purpose Postoperative nausea and vomiting (PONV) is a common adverse event after surgery. Remimazolam is a novel sedative agent recently approved for general anesthesia in Japan. This study evaluated the efficacy of remimazolam in the incidence of PONV after laparoscopic gynecological surgery under general anesthesia. Methods This prospective, randomized controlled trial included 64 women who underwent laparoscopic gynecological surgery. The patients were randomly assigned to undergo general anesthesia with either remimazolam (REM group) or desflurane (DES group, n  = 30, each group). The primary outcome was the incidence of PONV in the two groups at 2 h and 24 h after the surgery. The incidence of vomiting, rescue antiemetic use, and severity of nausea were also evaluated. Results In the REM group, the incidence of PONV (27% versus 60%, respectively; P  = 0.02), rescue antiemetic use (0 versus 7, respectively; P  = 0.01), and nausea score ( P  = 0.01) were significantly decreased during the first 2 h after surgery. No parameters were significantly different 24 h after surgery between the two groups. Conclusion Remimazolam can reduce the incidence of PONV after laparoscopic gynecological surgery compared to general anesthesia with desflurane during the early postoperative period.