Effects of Polyphenol Compounds and Nitrogen Oxide Donors on Lipid Oxidation, Membrane-Skeletal Proteins, and Erythrocyte Structure under Hypoxia

• Published in: BioMed research international Vol. 2019; no. 2019; pp. 1 - 15
• Main Authors: Incina, Vera I., Tairova, Marina R., Stepushkina, Olga G., Bochkareva, Svetlana S., Revina, Nadezhda V., Prosnikova, Ksenia V., Revina, Elvira S., Gromova, Natalia V., Revin, Victor V., Grunyushkin, Igor P.
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2019; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Adult; Antioxidants; Blood & organ donations; Blood circulation disorders; Cell membranes; Cells, Cultured; Cytology; Cytoskeleton; Erythrocytes; Erythrocytes - drug effects; Experiments; Flavonoids; Hemoglobin; Humans; Hypoxia; Hypoxia - metabolism; Isoflavones; Ligands; Lipid peroxidation; Lipid Peroxidation - drug effects; Lipids; Male; Medical research; Membrane proteins; Membrane Proteins - drug effects; Membranes; Middle Aged; Morphology; Nitric oxide; Nitric Oxide Donors - pharmacology; Nitrogen; Nitrogen oxide; Nitrogen oxides; Oxidation; Oxidative Stress - drug effects; Physiological aspects; Polyphenols - pharmacology; Proteins; Sodium; Sodium nitroprusside; Spectrum analysis; Russia
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2019/6758017

This study shows that membrane-associated cytoskeletal protein structures and the erythrocyte morphology undergo profound changes during hypoxia. Hypoxia also intensified oxidative processes in the lipid phase of the bilayer of red blood cell membranes. Sodium nitroprusside impaired the morphology of red blood cells and altered quantitative and qualitative composition of membrane-skeletal proteins. The findings suggest that hypoxia causes changes at all levels of red blood cell organization, which can cause the functional disorders of hemoglobin oxygen-transporting properties and, eventually, the complete degradation of red blood cells. The use of flavonoids has a protective effect against hypoxia.