The Effect of Polydeoxyribonucleotide on Chronic Non-healing Wound of an Amputee: A Case Report

Polydeoxyribonucleotide (PDRN) is safe and effective in wound healing, cellular growth, synthesis of extracellular matrix protein, and inflammation reduction via activation of adenosine A2 receptors. We report a 28-year-old male patient treated with PDRN injections for chronic non-healing wound refr...

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Bibliographic Details
Published inAnnals of rehabilitation medicine Vol. 42; no. 4; pp. 630 - 633
Main Authors Shin, Junho, Park, Gahee, Lee, Junhee, Bae, Hasuk
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Academy of Rehabilitation Medicine 01.08.2018
대한재활의학회
Subjects
Amputees
Case Report
Polydeoxyribonucleotides
Wound healing
재활의학
Amputees
Polydeoxyribonucleotides
Wound healing
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Summary:Polydeoxyribonucleotide (PDRN) is safe and effective in wound healing, cellular growth, synthesis of extracellular matrix protein, and inflammation reduction via activation of adenosine A2 receptors. We report a 28-year-old male patient treated with PDRN injections for chronic non-healing wound refractory to negative pressure wound therapy, skin graft, or growth factors. Three injections of PDRN were administered at the wound site into the anterior and medial sides of the left stump on the 1st, 4th, and 9th days of hospitalization. The PDRN ameliorated wound healing by enhancing cell growth, tissue repair, and angiogenesis. PDRN application represents a potential treatment for non-healing wounds obviating the need for additional therapies, and hospitalization, as well as improve patient's activities of daily living.
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ISSN:2234-0645
2234-0653
DOI:10.5535/arm.2018.42.4.630