RAD51 and XRCC3 Polymorphisms Are Associated with Increased Risk of Prostate Cancer

Genetic polymorphisms in DNA repair genes may affect DNA repair efficiency and may contribute to the risk of developing cancer. The aim of our study was to investigate single nucleotide polymorphisms (SNPs) in RAD51 (rs2619679, rs2928140, and rs5030789) and XRCC3 (rs1799796) involved in DNA double-s...

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Published inJournal of oncology Vol. 2019; no. 2019; pp. 1 - 8
Main Authors Krajewska, Wanda M., Bryś, Magdalena, Forma, Ewa, Kwasiborski, Tomasz, Raszkiewicz, Agata, Nowacka-Zawisza, Maria, Różański, Waldemar
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 01.01.2019
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects
Cancer
Deoxyribonucleic acid
Development and progression
DNA
DNA damage
Enzymes
Ethylenediaminetetraacetic acid
Genes
Genetic aspects
Mitochondrial DNA
Mutation
Oncology, Experimental
Polymerase chain reaction
Polymorphism
Prostate cancer
Proteins
Risk factors
Single nucleotide polymorphisms
Tumorigenesis
Poland
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Summary:Genetic polymorphisms in DNA repair genes may affect DNA repair efficiency and may contribute to the risk of developing cancer. The aim of our study was to investigate single nucleotide polymorphisms (SNPs) in RAD51 (rs2619679, rs2928140, and rs5030789) and XRCC3 (rs1799796) involved in DNA double-strand break repair and their relationship to prostate cancer. The study group included 99 men diagnosed with prostate cancer and 205 cancer-free controls. SNP genotyping was performed using the PCR-RFLP method. A significant association was detected between RAD51 rs5030789 polymorphism and XRCC3 rs1799796 polymorphism and an increased risk of prostate cancer. Our results indicate that RAD51 and XRCC3 polymorphism may contribute to prostate cancer.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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Guest Editor: Zhihua Kang
ISSN:1687-8450
1687-8450
1687-8469
DOI:10.1155/2019/2976373