The Serum Concentration of Vancomycin as a Diagnostic Predictor of Nephrotoxic Acute Kidney Injury in Critically Ill Patients

• Published in: Antibiotics (Basel) Vol. 11; no. 1; p. 112
• Main Authors: Zamoner, Welder, Eid, Karina Zanchetta Cardoso, de Almeida, Lais Maria Bellaver, Pierri, Isabella Gonçalves, Santos, Adriano Dos, Balbi, André Luis, Ponce, Daniela
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15.01.2022; MDPI
• Subjects: acute kidney injury; Bayesian analysis; Clinical outcomes; Creatinine; Diagnosis; Drug dosages; Intensive care; Kidneys; Laboratories; Monitoring; nephrotoxicity; Patients; Pharmacokinetics; Regression analysis; Sepsis; Vancomycin; Variables; vancomycin; acute kidney injury; nephrotoxicity; sepsis
• ISSN: 2079-6382; 2079-6382
• DOI: 10.3390/antibiotics11010112

The impact of serum concentrations of vancomycin is a controversial topic. 182 critically ill patients were evaluated using vancomycin and 63 patients were included in the study. AKI occurred in 44.4% of patients on the sixth day of vancomycin use. Vancomycin higher than 17.53 mg/L between the second and the fourth days of use was a predictor of AKI, preceding AKI diagnosis for at least two days, with an area under the curve of 0.806 (IC 95% 0.624-0.987, = 0.011). Altogether, 46.03% of patients died, and in the Cox analysis, the associated factors were age, estimated GFR, CPR, and vancomycin between the second and the fourth days. The current 2020 guidelines recommend using Bayesian-derived AUC monitoring rather than trough concentrations. However, due to the higher number of laboratory analyses and the need for an application to calculate the AUC, many centers still use therapeutic trough levels between 15 and 20 mg/L. The results of this study suggest that a narrower range of serum concentration of vancomycin was a predictor of AKI in critically ill septic patients, preceding the diagnosis of AKI by at least 48 h, and it can be a useful monitoring tool when AUC cannot be used.