Mass Cytometry Identifies Expansion of T-bet + B Cells and CD206 + Monocytes in Early Multiple Sclerosis

Multiple sclerosis (MS) is an immune-driven demyelinating disease of the central nervous system. Immune cell features are particularly promising as predictive biomarkers due to their central role in the pathogenesis but also as drug targets, even if nowadays, they have no impact in clinical practice...

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Published inFrontiers in immunology Vol. 12; p. 653577
Main Authors Couloume, Laura, Ferrant, Juliette, Le Gallou, Simon, Mandon, Marion, Jean, Rachel, Bescher, Nadège, Zephir, Helene, Edan, Gilles, Thouvenot, Eric, Ruet, Aurelie, Debouverie, Marc, Tarte, Karin, Amé, Patricia, Roussel, Mikael, Michel, Laure
Format Journal Article
LanguageEnglish
Published Switzerland Frontiers 04.05.2021
Frontiers Media S.A
Subjects
Adaptive immunology
B cells
biomarker
Immunology
Life Sciences
mass cytometry
monocytes
multiple sclerosis
Neurobiology
Neurons and Cognition
monocytes
B cells
mass cytometry
biomarker
immunology
multiple sclerosis
Biomarkers
Mass cytometry
Monocytes
Multiple sclerosis
Immunology
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Summary:Multiple sclerosis (MS) is an immune-driven demyelinating disease of the central nervous system. Immune cell features are particularly promising as predictive biomarkers due to their central role in the pathogenesis but also as drug targets, even if nowadays, they have no impact in clinical practice. Recently, high-resolution approaches, such as mass cytometry (CyTOF), helped to better understand the diversity and functions of the immune system. In this study, we performed an exploratory analysis of blood immune response profiles in healthy controls and MS patients sampled at their first neurological relapse, using two large CyTOF panels including 62 markers exploring myeloid and lymphoid cells. An increased abundance of both a T-bet-expressing B cell subset and a CD206 classical monocyte subset was detected in the blood of early MS patients. Moreover, T-bet-expressing B cells tended to be enriched in aggressive MS patients. This study provides new insights into understanding the pathophysiology of MS and the identification of immunological biomarkers. Further studies will be required to validate these results and to determine the exact role of the identified clusters in neuroinflammation.
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This article was submitted to Multiple Sclerosis and Neuroimmunology, a section of the journal Frontiers in Immunology
Reviewed by: Izumi Kawachi, Niigata University, Japan; Nancy Monson, University of Texas Southwestern Medical Center, United States
Edited by: Jorge Matias-Guiu, Complutense University of Madrid, Spain
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2021.653577