Dimerization of retroviral RNA genomes: an inseparable pair

Many viruses carry more than one segment of nucleic acid into the virion particle, but retroviruses are the only known group of viruses that contain two identical (or nearly identical) copies of the RNA genome within the virion. These RNA genomes are non-covalently joined together through a process...

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Published inNature reviews. Microbiology Vol. 2; no. 6; pp. 461 - 472
Main Authors Marquet, Roland, Mak, Johnson, Paillart, Jean-Christophe, Shehu-Xhilaga, Miranda
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.06.2004
Subjects
Base Sequence
Dimerization
Genome, Viral
Genomes
HIV-1 - genetics
HIV-1 - growth & development
Human immunodeficiency virus 1
Humans
Models, Molecular
Molecular Sequence Data
NMR
Nuclear magnetic resonance
Nucleic Acid Conformation
Nucleic acids
Proteins
Viral infections
Virus Replication - genetics
Australia
Victoria Australia
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Summary:Many viruses carry more than one segment of nucleic acid into the virion particle, but retroviruses are the only known group of viruses that contain two identical (or nearly identical) copies of the RNA genome within the virion. These RNA genomes are non-covalently joined together through a process known as genomic RNA dimerization. Uniquely, the RNA dimerization of the retroviral genome is of crucial importance for efficient retroviral replication. In this article, our current understanding of the relationship between retroviral genome conformation, dimerization and replication is reviewed.
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ISSN:1740-1526
1740-1534
DOI:10.1038/nrmicro903