Engineered extracellular vesicles: potentials in cancer combination therapy

Extracellular vesicles (EVs) are a group of secretory vesicles with cell-derived membrane and contents. Due to the cargo delivery capability, EVs can be designed as drug delivery platforms for cancer therapy. Biocompatibility and immune compatibility endow EVs with unique advantages compared with ot...

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Published inJournal of nanobiotechnology Vol. 20; no. 1; p. 132
Main Authors Chen, Jiangbin, Tan, Qi, Yang, Zimo, Jin, Yang
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 15.03.2022
BioMed Central
BMC
Subjects
Biological products
Biomedical engineering
Cancer
Cancer therapy
Care and treatment
Cell Communication
Cell organelles
Combinational therapy
Combined Modality Therapy
Drug delivery systems
Drug Delivery Systems - methods
Drugs
Engineered EVs
Equipment and supplies
Extracellular Vesicles
Extracellular vesicles (EVs)
Health aspects
Humans
Methods
Neoplasms - drug therapy
Oncology, Experimental
Physiological aspects
Review
Tumor Microenvironment
Vehicles
China
Engineered EVs
Extracellular vesicles (EVs)
Cancer therapy
Combinational therapy
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Summary:Extracellular vesicles (EVs) are a group of secretory vesicles with cell-derived membrane and contents. Due to the cargo delivery capability, EVs can be designed as drug delivery platforms for cancer therapy. Biocompatibility and immune compatibility endow EVs with unique advantages compared with other nanocarriers. With the development of this field, multiple ingenious modification methods have been developed to obtain engineered EVs with desired performance. Application of engineered EVs in cancer therapy has gradually shifted from monotherapy to combinational therapy to fight against heterogeneous cancer cells and complex tumor microenvironment. In addition, the strong plasticity and load capacity of engineered EV make it potential to achieve various combinations of cancer treatment methods. In this review, we summarize the existing schemes of cancer combination therapy realized by engineered EVs, highlight the mechanisms and representative examples of these schemes and provide guidance for the future application of engineered EVs to design more effective cancer combination treatment plans.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:1477-3155
1477-3155
DOI:10.1186/s12951-022-01330-y