Biocompatible Carbon-Based Coating as Potential Endovascular Material for Stent Surface

• Published in: BioMed research international Vol. 2018; no. 2018; pp. 1 - 10
• Main Authors: Wozniak, Mieczyslaw, Frączkowska, Kaja, Duda, Maciej, Kopaczyńska, Marta, Podbielska, Halina, Bialy, Dariusz, Sawicki, Grzegorz, Stręk, Wiesław, Hreniak, Dariusz, Łukaszewicz, Mikołaj, Arkowski, Jacek, Krzywonos-Zawadzka, Anna, Bil-Lula, Iwona, Wawrzynska, Magdalena, Drab, Marek
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Atomic beam spectroscopy; Atomic force microscopy; Biocompatibility; Blood clot; Cardiovascular system; Cell growth; Coated Materials, Biocompatible - chemistry; Endothelial cells; Endothelial Cells - metabolism; Endothelium; Genotype & phenotype; Graphene; Graphite; Humans; Implants; Materials Testing; Mechanical properties; Mesenchyme; Phenotypes; Production methods; Raman spectroscopy; Restenosis; Scanning electron microscopy; Smooth muscle; Spectrum analysis; Stainless steel; Steel alloys; Steel, Stainless; Stem cells; Stent (Surgery); Stents; Substrates; Surface Properties; Surgical implants; Thromboembolism; Thrombosis; Transplants & implants; Poland
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2018/2758347

Stainless steel 316L is a material commonly used in cardiovascular medicine. Despite the various methods applied in stent production, the rates of in-stent restenosis and thrombosis remain high. In this study graphene was used to coat the surface of 316L substrate for enhanced bio- and hemocompatibility of the substrate. The presence of graphene layers applied to the substrate was investigated using cutting-edge imaging technology: energy-filtered low-voltage FE-SEM approach, scanning electron microscopy (SEM), Raman spectroscopy, and atomic force microscopy (AFM). The potential of G-316L surface to influence endothelial cells phenotype and endothelial-to-mesenchymal transition (EndoMT) has been determined. Our results show that the bio- and hemocompatible properties of graphene coatings along with known radial force of 316L make G-316L a promising candidate for intracoronary implants.