Two-Photon Vision in Age-Related Macular Degeneration: A Translational Study

The recently introduced term “two-photon vision” relates to the visual perception resulting from a simultaneous absorption of two photons by photoreceptors. In this study, we determined two-photon retinal sensitivity in age-related macular degeneration (AMD) and compared it that in normal aging. Mic...

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Published inDiagnostics (Basel) Vol. 12; no. 3; p. 760
Main Authors Łabuz, Grzegorz, Zielińska, Agnieszka, Kessler, Lucy J, Rayamajhi, Asu, Komar, Katarzyna, Khoramnia, Ramin, Auffarth, Gerd U
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 21.03.2022
MDPI
Subjects
AMD
Atrophy
Biomarkers
Diabetes
Diabetic retinopathy
Disease
Lasers
Light
Macular degeneration
microperimetry
Morphology
normal aging
Photoreceptors
Retina
retinal sensitivity
Software
two-photon vision
Visual perception
Germany
AMD
normal aging
two-photon vision
microperimetry
retinal sensitivity
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Summary:The recently introduced term “two-photon vision” relates to the visual perception resulting from a simultaneous absorption of two photons by photoreceptors. In this study, we determined two-photon retinal sensitivity in age-related macular degeneration (AMD) and compared it that in normal aging. Microperimetry was performed with visible (white) light and infrared (IR) light, which was perceived as green in the two-photon stimulation. In total, 45 subjects were included with one (better) eye studied. Furthermore, best-corrected visual acuity (VA) and ocular straylight were assessed. AMD resulted in decreased median (interquartile range) logMAR VA, i.e., 0.15 (0.05; 0.24), which in normal eyes was −0.02 (−0.06; 0.02). The two groups showed comparable straylight levels. Sensitivity to IR light was significantly lower in the AMD group (p < 0.001): 8.3 (7.4, 9.3) dB than in controls 10.7 (9.7, 11.2) dB. AMD also significantly affected visible light sensitivity (p < 0.001): 14.0 (11.0; 15.5) dB vs. 18.0 (16.3; 18.9) dB. Notably, the two-photon approach yielded a lower data spread. In conclusion, AMD considerably impairs retinal sensitivity measured in the single- and two-photon realm. However, two-photon-vision microperimetry may improve the testing accuracy and offer an additional diagnostic parameter (beyond VA measurements) for retinal function assessment.
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These authors contributed equally to this work.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12030760