Discovery of MK8383s with Antifungal Activity from Mangrove Endophytic Fungi Medicopsis sp. SCSIO 40440 Against Fusarium Wilt of Banana

• Published in: Marine drugs Vol. 23; no. 2; p. 88
• Main Authors: Zhou, Tianyu, Qiao, Yulei, Wang, Lu, Li, Zifeng, Zhang, Haibo, Zhang, Liping, Liao, Shengrong, Li, Minhui, Zhang, Changsheng, Zhang, Wenjun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2025; MDPI
• Subjects: antifungal activities against Foc TR4; Antifungal activity; Antifungal agents; Antifungal Agents - chemistry; Antifungal Agents - isolation & purification; Antifungal Agents - pharmacology; Bananas; Bioactive compounds; Chromatography; decalin carboxylic acids; Diffraction; Drug Discovery; Endophytes; Endophytes - chemistry; Enzymes; Fermentation; Fruit industry; Fruits; Fungi; Fungicides; Fusarium; Fusarium - drug effects; Fusarium - pathogenicity; Fusarium oxysporum; Hygromycin; Hygromycin B; mangrove endophytic fungi; Mangroves; Metabolites; Microbial Sensitivity Tests; Musa - microbiology; Natural products; Nystatin; Plant Diseases - microbiology; Plant Diseases - prevention & control; Single crystals; Spores; Virulence; Wilt; X-ray diffraction; X-ray diffraction analysis; X-rays; China; antifungal activities against Foc TR4; decalin carboxylic acids; mangrove endophytic fungi

Fusarium wilt of banana (FWB), caused by Fusarium oxysporum f. sp. cubense (Foc) tropical race 4 (TR4), poses a severe threat to the global banana industry. The screening of endophytic fungi from the mangrove plant led to the identification of Medicopsis sp. SCSIO 40440, which exhibited potent antif...