Serum Levels of TNF-α Are Increased in Patients with Rotator Cuff Tear and Sleep Disturbance

• Published in: Diagnostics (Basel) Vol. 11; no. 12; p. 2215
• Main Authors: Cho, Chul-Hyun, Kim, Du-Hwan, Baek, Eun-Hee, Kim, Du-Han
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 27.11.2021; MDPI
• Subjects: Arthritis; cytokine; Cytokines; Disease; Hypotheses; Pain; Pathophysiology; Questionnaires; Rotator cuff; Shoulder; Sleep; Surgery; Tumor necrosis factor-TNF; tumor necrosis factor-α; Womens health; United States > US; cytokine; sleep; rotator cuff; tumor necrosis factor-α
• ISSN: 2075-4418; 2075-4418
• DOI: 10.3390/diagnostics11122215

The purpose of this study was to determine serum levels of sleep-related cytokines in patients with rotator cuff tear (RCT) who were experiencing pain-related sleep disturbance. Peripheral blood samples before surgery were collected from 63 study participants and divided into three groups: RCT with sleep disturbance group; SD group ( = 21), RCT with normal sleep group; NS group ( = 21), and patients with chronic shoulder instability; control group ( = 21). Serum concentration levels of interleukin-1α (IL-1α), IL-1β, IL-2, IL-6, IL-8, IL-10, and tumor necrosis factor-α (TNF-α) were measured via ELISA. The associations between serum levels of sleep-related cytokines and clinical scores and the Pittsburgh Sleep Quality Index (PSQI) were analyzed. Serum concentration levels of TNF-α were significantly higher in the SD group compared with those of the NS and control groups ( = < 0.001 and 0.05). Serum levels of IL-8 and IL-10 were significantly higher in the SD group compared with those of control group ( = 0.01 and = 0.05), but did not differ significantly from that of the NS group. There were no associations between serum levels of sleep-related cytokines and all clinical scores. The current findings suggest that TNF-α may be associated with sleep disturbance in patients with RCT.