Neuronal immunoglobulin superfamily cell adhesion molecules in epithelial morphogenesis: insights from Drosophila

• Published in: Philosophical transactions of the Royal Society of London. Series B. Biological sciences Vol. 375; no. 1809; p. 20190553
• Main Authors: Finegan, Tara M, Bergstralh, Dan T
• Format: Journal Article
• Language: English
• Published: England The Royal Society 12.10.2020
• Subjects: Animals; Cell Adhesion Molecules, Neuronal - metabolism; Drosophila - embryology; Embryo, Nonmammalian - embryology; Epithelial Cells - cytology; Immunoglobulins - metabolism; Morphogenesis; Review; epithelial junctions; cell–cell adhesion; immunoglobulin superfamily
• ISSN: 0962-8436; 1471-2970
• DOI: 10.1098/rstb.2019.0553

In this review, we address the function of immunoglobulin superfamily cell adhesion molecules (IgCAMs) in epithelia. Work in the model system in particular has revealed novel roles for calcium-independent adhesion molecules in the morphogenesis of epithelial tissues. We review the molecular composition of lateral junctions with a focus on their IgCAM components and reconsider the functional roles of epithelial lateral junctions. The epithelial IgCAMs discussed in this review have well-defined roles in the nervous system, particularly in the process of axon guidance, suggesting functional overlap and conservation in mechanism between that process and epithelial remodelling. We expand on the hypothesis that epithelial occluding junctions and synaptic junctions are compositionally equivalent and present a novel hypothesis that the mechanism of epithelial cell (re)integration and synaptic junction formation are shared. We highlight the importance of considering non-cadherin-based adhesion in our understanding of the mechanics of epithelial tissues and raise questions to direct future work. This article is part of the discussion meeting issue 'Contemporary morphogenesis'.