RANKL/RANK/OPG Pathway: A Mechanism Involved in Exercise-Induced Bone Remodeling

• Published in: BioMed research international Vol. 2020; no. 2020; pp. 1 - 11
• Main Authors: Jafarnejad, Sadegh, Amin, Negin, Moghadasian, Mohammed H., Tobeiha, Mohammad
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Alendronate; B cells; Biomedical materials; Bone diseases; Bone marrow; Bone remodeling; Bone turnover; Bones; Calcification; Cancer; Denosumab; Exercise; Health; Kinases; Ligands; Metabolism; Osteopenia; Osteoporosis; Osteoprotegerin; Physical activity; Physical fitness; Physical training; Physiological aspects; Proteins; Review; Risk analysis; Risk factors; Roles; Stem cells; System effectiveness; TRANCE protein; Womens health
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2020/6910312

Bones as an alive organ consist of about 70% mineral and 30% organic component. About 200 million people are suffering from osteopenia and osteoporosis around the world. There are multiple ways of protecting bone from endogenous and exogenous risk factors. Planned physical activity is another useful way for protecting bone health. It has been investigated that arranged exercise would effectively regulate bone metabolism. Until now, a number of systems have discovered how exercise could help bone health. Previous studies reported different mechanisms of the effect of exercise on bone health by modulation of bone remodeling. However, the regulation of RANKL/RANK/OPG pathway in exercise and physical performance as one of the most important remodeling systems is not considered comprehensive in previous evidence. Therefore, the aim of this review is to clarify exercise influence on bone modeling and remodeling, with a concentration on its role in regulating RANKL/RANK/OPG pathway.