Frontal phasic and oscillatory generators of the N30 somatosensory evoked potential

• Published in: NeuroImage (Orlando, Fla.) Vol. 54; no. 2; pp. 1297 - 1306
• Main Authors: Cebolla, A.M., Palmero-Soler, E., Dan, B., Cheron, G.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 15.01.2011; Elsevier Limited
• Subjects: Adult; Brain; Brain Mapping; Brain research; Cortex (frontal); Cortex (motor); Cortex (premotor); Cortex (somatosensory); EEG; Electrodes; Electroencephalography; Event-related potentials; Evoked Potentials, Somatosensory - physiology; Female; Frequency dependence; Frontal Lobe - physiology; Generators; Humans; Latency; Male; Parkinson's disease; Prefrontal cortex; Sensorimotor system; Software; Somatosensory evoked potentials; Synchronization; Netherlands
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2010.08.060

The N30 component of somatosensory evoked potentials has been recognized as a crucial index of brain sensorimotor processing and has been increasingly used clinically. Previously, we have shown that the N30 is accompanied by both an increase of the power spectrum of the ongoing beta-gamma EEG (event related synchronization, ERS) and by a reorganization (phase-locking) of the spontaneous phase of this rhythm (inter-trials coherency, ITC). In order to localize its sources taking into account both the phasic and oscillatory aspects of the phenomenon, we here apply swLORETA methods on averaged signals of the event-related potential (ERP) from a 128 scalp-electrodes array in time domain and also on raw EEG signals in frequency domain at the N30 peak latency. We demonstrate that the two different mechanisms that generate the N30 component power increase (ERS) and phase locking (ITC) across EEG trials are spatially localized in overlapping areas in the precentral cortex, namely the motor cortex (BA4) and the premotor cortex (BA6). From this common region, the generator of the N30 event-related potential expands toward the posterior part of BA4, the anterior part of BA6 and the prefrontal cortex (BA9). These latter areas also present significant ITC sources in the beta-gamma frequency range, but without significant power increase of this rhythm. This demonstrates that N30 results from network activity that depends on distinct oscillating and phasic generators localized in the frontal cortex. ►N30 results from distinct oscillating and phasic generators in frontal cortex. ►Beta-gamma power increase and phase locking generating N30 are precentrally localized. ►Beta-gamma phase locking in prefrontal cortex is not accompanied by power increase.