Quantitative evaluation of bone metastases from prostate cancer with simultaneous [18F] choline PET/MRI: combined SUV and ADC analysis

• Published in: Annals of nuclear medicine Vol. 28; no. 5; pp. 405 - 410
• Main Authors: Wetter, Axel, Lipponer, Christine, Nensa, Felix, Heusch, Philipp, Rübben, Herbert, Schlosser, Thomas W., Pöppel, Thorsten D., Lauenstein, Thomas C., Nagarajah, James
• Format: Journal Article
• Language: English
• Published: Tokyo Springer Japan 01.06.2014; Springer Nature B.V
• Subjects: Aged; Aged, 80 and over; Biological Transport; Bone Neoplasms - diagnosis; Bone Neoplasms - diagnostic imaging; Bone Neoplasms - metabolism; Bone Neoplasms - secondary; Carbon Radioisotopes; Choline - metabolism; Diffusion; Fluorodeoxyglucose F18 - metabolism; Humans; Imaging; Magnetic Resonance Imaging; Male; Medicine; Medicine & Public Health; Middle Aged; Multimodal Imaging; Nuclear Medicine; Original Article; Positron-Emission Tomography; Prostatic Neoplasms - pathology; Radiology; Recurrence; Time Factors; ADC; PET/MRI; F] choline; [; Prostate cancer; Bone metastases
• ISSN: 0914-7187; 1864-6433
• DOI: 10.1007/s12149-014-0825-x

Objective To quantitatively analyze bone metastases from prostate cancer and correlate the apparent diffusion coefficients (ADCs) and standardized uptake values (SUVs). Methods Fifty-five patients with biopsy-proven prostate cancer or suspected recurrent prostate cancer were examined with simultaneous [ 18 F] choline Positron emission tomography (PET)/MRI at 3 T. In 11 patients, thirty-two PET-positive bone lesions could be identified that were located in the field-of-view of the Diffusion weighted imaging-sequence. Region-of-interest and volume-of-interest analyses were performed to measure the mean and minimal ADCs and to assess maximum and mean SUVs of every bone lesion. Correlations between maximum and mean SUVs and mean and minimal ADCs were calculated. Results The SUV max of all lesions was 5.5 ± 3.1 (mean ± SD). The SUV mean was 1.8 ± 0.9. The mean ADC (ADC mean ) of all lesions was 0.67 ± 0.13 × 10 −3  mm 2 /s. The minimal ADC (ADC min ) of all lesions was 0.56 ± 0.14 × 10 −3  mm 2 /s. There was a moderate but significant inverse correlation of SUV max vs. ADC mean with a correlation coefficient of −0.4 ( p  = 0.02). There was also a significant inverse correlation of SUV max vs. ADC min with r  = −0.41 ( p  = 0.02). Conclusion Our initial results demonstrate a moderate but significant inverse correlation between increased choline metabolism and ADC values of bone metastases from prostate cancer. Further research on a multimodality approach using simultaneous PET/MRI in bone metastasis of prostate cancer seems to be justified.