COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management

• Published in: Frontiers in pharmacology Vol. 11; p. 563478
• Main Authors: Hossain, Md Farhad, Hasana, Sharifa, Mamun, Abdullah Al, Uddin, Md Sahab, Wahed, Mir Imam Ibne, Sarker, Sabarni, Behl, Tapan, Ullah, Irfan, Begum, Yesmin, Bulbul, Israt Jahan, Amran, Md Shah, Rahman, Md Habibur, Bin-Jumah, May N, Alkahtani, Saad, Mousa, Shaker A, Aleya, Lotfi, Abdel-Daim, Mohamed M
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers 16.10.2020; Frontiers Media S.A
• Subjects: coronavirus; coronavirus disease 2019; Environmental Sciences; Middle East respiratory syndrome coronavirus; Pharmacology; severe acute respiratory syndrome coronavirus-2; therapeutic interventions; transmission; therapeutic interventions; Middle East respiratory syndrome coronavirus; coronavirus; severe acute respiratory syndrome coronavirus-2; transmission; coronavirus disease 2019
• ISSN: 1663-9812; 1663-9812
• DOI: 10.3389/fphar.2020.563478

At the end of 2019, a novel coronavirus (CoV) was found at the seafood market of Hubei province in Wuhan, China, and this virus was officially named coronavirus diseases 2019 (COVID-19) by World Health Organization (WHO). COVID-19 is mainly characterized by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and creates public health concerns as well as significant threats to the economy around the world. Unfortunately, the pathogenesis of COVID-19 is unclear and there is no effective treatment of this newly life-threatening and devastating virus. Therefore, it is crucial to search for alternative methods that alleviate or inhibit the spread of COVID-19. In this review, we try to find out the etiology, epidemiology, symptoms as well as transmissions of this novel virus. We also summarize therapeutic interventions and suggest antiviral treatments, immune-enhancing candidates, general supplements, and CoV specific treatments that control replication and reproduction of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV).