Ebolavirus’s Foibles

Ebola virus disease poses a global health threat. Here, two studies by Wec et al. and Zhao et al. identified vulnerability in an internal fusion loop of an ebolavirus glycoprotein. Monoclonal antibodies elicited from immunization and isolated from a human survivor that recognized epitopes in this ar...

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Bibliographic Details
Published inCell Vol. 169; no. 5; pp. 773 - 775
Main Authors Yamayoshi, Seiya, Kawaoka, Yoshihiro
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 18.05.2017
Subjects
Animals
Antibodies, Monoclonal - immunology
Antibodies, Viral - immunology
Ebolavirus
Ebolavirus - immunology
epitopes
Epitopes - immunology
glycoproteins
Hemorrhagic Fever, Ebola - immunology
Humans
immunization
Mice
Mice, Inbred BALB C
monoclonal antibodies
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Summary:Ebola virus disease poses a global health threat. Here, two studies by Wec et al. and Zhao et al. identified vulnerability in an internal fusion loop of an ebolavirus glycoprotein. Monoclonal antibodies elicited from immunization and isolated from a human survivor that recognized epitopes in this area neutralized all five ebolaviruses, guiding the development of a pan-ebolavirus immunotherapy. Ebola virus disease poses a global health threat. Here, two studies by Wec et al. and Zhao et al. identified vulnerability in an internal fusion loop of an ebolavirus glycoprotein. Monoclonal antibodies elicited from immunization and isolated from a human survivor that recognized epitopes in this area neutralized all five ebolaviruses, guiding the development of a pan-ebolavirus immunotherapy.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Commentary-3
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ISSN:0092-8674
1097-4172
1097-4172
DOI:10.1016/j.cell.2017.05.008